Research topics in brief

Biomedical applications

  • Alpha-1 Antitrypsin Inhibits Caspase-3 Activity, Preventing Lung Endothelial Cell Apoptosis. Petrache I. et al., Am. J. Path. 2006. [pdf]
  • Abnormal Sterols in Cholesterol-Deficiency Diseases Cause Secretory Granule Malformation and Decreased Membrane Curvature. Gondre-Lewis et al., J. Cell Science, 2006. [pdf]

Ionic interactions in solution, forces between membranes: hydration, van der Waals, electrostatics

  • Osmotically-induced reversible transitions in lipid-DNA mesophases. Danino et al., Biophys. J., 2009. [pdf]
  • Interfacial Polar Interactions Affect Gramicidin Channel Kinetics. Rostovtseva et al., Biophys. J., 2008. [pdf]
  • Salt Screening and Specific Ion Adsorption Determine Neutral-Lipid Membrane Interactions. Proc. Natl. Acad. Sci., 2006, 103:7982-7987. [pdf]
  • Salt Screening and Specific Ion Adsorption Determine Neutral-Lipid Membrane Interactions. Proc. Natl. Acad. Sci., 2006, 103:7982-7987. [pdf]
  • Swelling of Phospholipids by Monovalent Salt. J. Lipid Res. 2006, [pdf]
  • Measured Depletion of Ions at the Biomembrane Interface. J. Am. Chem. Soc., 2005. [pdf]
  • Structure and Fluctuations of Charged Phophatidylserine Bilayers in the Absence of Salt. Biophys. J. 2004. [pdf]

Polyunsaturated (dietary) lipids

  • Packing and Viscoelasticity of Polyunsaturated omega-3 and omega-6 Lipid Bilayers as seen by 2H NMR and X-ray Diffraction. J. Am. Chem. Soc., 2005. Rajamoorthi et al. [pdf]
  • Structural Properties of Docosahexaenoyl Phospholipid Bilayers Investigated by Solid-state 2H NMR Spectroscopy. J. Am. Chem. Soc. 2001, 123:12611-12622. [pdf]

Membrane structure from X-ray scattering (SAXS), NMR, and MD

  • Phase separation in binary mixtures of bipolar and monopolar lipid dispersions revealed by 2H NMR spectroscopy, small-angle x-ray scattering, and molecular theory. Biophys. J. 2009. Brownholland et al. [pdf]
  • Structure of Fully Hydrated Fluid Phase DMPC and DLPC Lipid Bilayers Using X-Ray Scattering from Oriented Multilamellar Arrays and from Unilamellar Vesicles. Biophys. J. 2005. Kucerka et al. [pdf]
  • Interpretation of Small Angle X-ray Measurements Guided by Molecular Dynamics Simulations of Lipid Bilayers. Chem. Phys. Lipids. 2003. Sachs et al. [pdf]
  • Area per Lipid and Acyl Length Distributions in Fluid Phosphatidylcholines Determined by 2H NMR Spectroscopy. Biophys. J. 2000. [pdf]
  • Analysis of Simulated NMR Order Parameters for Lipid Bilayer Structure Determination. Biophys. J. 1999. [pdf]
  • Determination of Component Volumes of Lipid Bilayers from Simulations. Biophys. J. 1997, 72:2237-2242. [pdf]

Membrane elasticity (spontaneous curvature and bending fluctuations)

  • Alteration of Lipid Membrane Rigidity by Cholesterol and Its Metabolic Precursors. Macromol. Symp., 2005. [pdf]
  • Structure and Interactions of Fluid Phospholipid Bilayers Measured by High Resolution X-ray Scattering, Ph.D. Thesis, Carnegie Mellon University, 1998. [pdf]
  • Interbilayer Interactions from High Resolution X-Ray Scattering. Phys. Rev. E 1998, 57:7014-7024. [pdf]